What is ovarian cancer

The ovaries are glands that contain the germ cells or eggs. Ovarian cancers begin when normal cells in an ovary change and grow uncontrollably, forming a mass called a tumor. A tumor can be benign (noncancerous) or malignant (cancerous, meaning it can spread to other parts of the body). Removing the ovary or the part of the ovary where the tumor is located can treat a noncancerous ovarian tumor. An ovarian cyst, which forms on the surface of the ovary, is different than a noncancerous tumor and usually goes away without treatment. An ovarian cyst is not always cancerous.

Magnitude of problem

Ovarian cancer is the second commonest gynecological cancer in our country. Approximately 28000 new patients are diagnosed every year in India alone.

A risk factor is something that increases your chances of developing a health condition such as cancer. Having a particular risk factor does not mean you definitely will get cancer, just as people without any known risk factors can develop cancer.

  • Age: risk of ovarian cancer is usually low below 50. A distinct variety of ovarian cancers known as germ cell tumors tend to occur in younger populations
  • Women who have not had children are slightly more likely to develop ovarian cancer, although the risk is still very low
  • Starting your periods early or having a late menopause slightly increases your risk of ovarian cancer
  • Using hormone replacement therapy (HRT) can slightly increase the risk. When HRT is stopped the risk of ovarian cancer gradually reduces to the same level as women who haven't taken HRT
  • Infertility may slightly increase the risk of developing ovarian cancer
  • Endometriosis – a condition where the womb lining grows outside the womb – may increase your risk of ovarian cancer
  • Being overweight may increase your risk of developing ovarian cancer
  • Eating a diet high in animal fats and low in fresh fruit and vegetables may also increase your risk
  • Genetics: Risk is higher in
    Women who have had breast cancer
    Who have family history of breast and/or ovarian cancer

Having one elderly relative with ovarian cancer doesn't necessarily increase your risk of ovarian cancer.

Most women with early-stage cancer of the ovary don't have any symptoms. When symptoms occur they may include any of the following

  • loss of appetite
  • indigestion, nausea, excessive gas (wind) and a bloated, full feeling
  • unexplained weight gain or an increased waist size
  • swelling in the abdomen – this may be due to lump in the abdomen in early stages or collection of fluid in advanced stages
  • pain in the lower abdomen
  • changes in bowel or bladder habits, such as constipation, diarrhoea or needing to pass urine more often
  • lower back pain
  • pain during sex
  • abnormal vaginal bleeding, although this is rare

If you have any of the above symptoms it's important to have them checked by your doctor, but remember they are common with many other conditions and most women with these symptoms will not have cancer.

Diagnosis

Diagnosis is usually made by clinical examination, CA-125 , a chest X ray and an ultrasound or CT scan(if required). CA125 is a protein that women normally have in their blood. The level may be higher in women with ovarian cancer, as it's sometimes produced by ovarian cancer cells. However, raised levels of CA125 can also be found in some other types of cancer and in women who have other non-cancerous conditions.

All these investigations give an idea about the extent of disease.

What does stage mean

The stage of a cancer is a term used to describe its extent and whether or not it has spread beyond its original site. Knowing the extent of the cancer helps the doctors decide on the most appropriate treatment for you. It's often not possible to stage an ovarian cancer before a laparotomy is done and the results of any biopsies are known. In stage I the disease is usually limited to the ovaries and in stage IV it has spread to distant organs like lung, liver, spleen.

Treating ovarian cancer

The main treatments used for ovarian cancer are surgery and chemotherapy. Choosing the right treatment for you will depend on many factors, including the stage and grade of the cancer, and your age and general health. Once your specialist has all the details about your cancer he or she will be able to discuss the best treatment for your situation.

Though treatment varies according to each woman's situation, generally:

  • Surgery is the main treatment for most women with ovarian cancer. For women with very early ovarian cancer, surgery may be the only treatment needed
  • Sometimes, chemotherapy is given before the operation to make it easier to remove any tumors by shrinking them
  • If the cancer is very advanced or if a woman isn't well enough for a major operation, chemotherapy may be the main treatment used
  • Radiotherapy usually has no role in treatment of ovarian cancer
  • Even if the cancer can't be cured, treatment can shrink the cancer and relieve symptoms so that the person feels better
Planning treatment

Treatment is usually planned taking into consideration a number of factors. These will include patient's age, general health, blood tests, the type and size of the tumor, what it looks like under the microscope and whether it has spread beyond the ovary (the stage).

Coping with the diagnosis

Cancer can affect many areas of patient's life such as finances, work, emotions and relationships. Absorbing the news of cancer diagnosis, communicating with the doctor, seeking support are some measures. Don't lose hope, take care of yourself. Survivors can help other people affected by cancer. Campaign for a better deal, give your time, share your experiences or make a donation.

Screening

Screening is a method to detect the disease early so that they can be treated more effectively. Currently routine screening for ovarian cancer is not recommended. However, women are high risk may get a vaginal ultrasound and CA-125 test done every six monthly.

Preventive measures
  • Having children may decrease your risk of ovarian cancer, and having two or more children may provide more protection than just one
  • Breastfeeding your children may slightly decrease your risk
  • Women who take the contraceptive pill are less likely to develop ovarian cancer
  • Last but not the least, Be aware, don't ignore your symptoms and consult a specialist at the earliest